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However, there is now a substantial literature of genetic association studies of UA-related genes and PD
Kritas, S
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some supportive measures used to prevent or reduce it are adjustment of drugs with possible interactions, hyperhydration, alkalinization to favor the elimination of methotrexate metabolites (7-OH-methotrexate and 4-deoxy-4-amino-N-10-methylpteroic acid), and leucovorin salvage and even new alternatives have been sought, such as the use of silymarin [104, 105]
In summary, advancement in understanding the tumorigenesis and progression of breast cancer form the foundation for improvements in systemic treatment
Milligan et al., 2022)
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