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181-190, Katib, Atif
Jessani S, Millane T, Lip GY
Semaglutide's 7-day half-life means it circulates longer than tirzepatide (5 days), giving you a wider window before missing a dose meaningfully impacts appetite control
They improve glycemic control through several mechanisms: Increasing insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing inappropriately high glucagon secretion Slowing gastric emptying which stabilizes blood glucose excursions Supporting beta cell proliferation to help preserve insulin production over time Reducing appetite and calorie intake leading to weight loss In patients with type 2 diabetes not meeting glycemic targets on other oral medications like metformin, adding a GLP-1 drug allows many to achieve hemoglobin A1c reductions of 0.7-1.6%.(40) This significantly improves diabetes control and lowers risks of long-term vascular complications
Accordingly, it will be interesting in the future to study the radiosensitivity of cells after simultaneously stimulating the transcription factors responsible for transcriptional induction of seleno-GPxs as well as increasing the availability of the inorganic selenium pool through selenium supplementation for efficient translation
