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SEP15) is highly expressed in several tissues, including prostate, kidney, testes, liver, and brain (29)

In addition, the gut microbiota can produce neurotransmitters such as acetylcholine, norepinephrine, and gamma-aminobutyric acid (Lyte, 2014), which connect with the metabolically dependent immune pathways through the sympathetic nervous system (SNS) to control the function of the kidney (liewska et al., 2019

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