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Hammond CL, Marchan R, Krance SM, Ballatori N

[7] The permeation challenge creates an important interpretive problem for the clinical data

In rare cases, side effects may include allergic reactions or interactions with certain medications

That's one biological pathway, replenished, doing what it always did before it ran low

A reasonable titration schedule might look like this: Week 1: 200mcg once daily Week 2: 300mcg once daily Week 3 onward: 300-500mcg based on response and tolerance Optimizing injection technique Poor injection technique contributes to injection site reactions and potentially to other effects like nausea from anxiety around the process