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FDA also states that available safety information is absent or limited and that serious adverse events have been identified as potentially associated, while causality remains unclear

Because of the potential for life-threatening complications and sequelae, management starts immediately with supportive measures: intravenous maintenance fluid, nutritional supplementation, and consultations with burn units or other specialists to minimize long-term sequelae such as ocular, renal, lung, liver, or genitourinary involvement

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As an E3 ubiquitin ligase, FBXO22 mediates the proteasomal degradation of multiple substrates

doi: 10.3389/fcvm.2026.1912835 Received 18 June 2026 Revised 15 July 2026 Accepted 22 July 2026 Published 31 July 2026 Volume 13 - 2026 Edited by Ashton Faulkner, Royal Veterinary College (RVC), United Kingdom Reviewed by Gabriel Komla Adzika, University of Pennsylvania, United States David Renaud, University of Innsbruck, Austria Updates Copyright 2026 Liu, Liu, Huang, Ouyang and Li