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The integrated stress response (ISR), defined by stress-triggered phosphorylation of eukaryotic initiation factor 2 (eIF2) and subsequent translational activation of transcription factor ATF4, is a conserved adaptive pathway that suppresses global protein synthesis whilst reshaping cellular metabolism [19]

Observed findings depend on route, formulation, concentration, and study design

2 The circadian clock regulates the abundance of mitochondrial complex I, related to Fig

SIDE EFFECTS OF TAKING HIKARI