For women, significant hormone fluctuations during the years leading up to menopause ( perimenopause ) can cause disruptive symptoms like hot flashes, sleep problems, mood swings, weight changes, inflammation, and more
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Mol Cell Endocrinol 418:4254 Lorenz M, Evers A, Wagner M (2013) Recent progress and future options in the development of GLP-1 receptor agonists for the treatment of diabesity