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In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems to get worse

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A plausible explanation could be a reorientation of Lys105 towards GS resulting in a decreased stabilization of the active site thiolate as a leaving group

Baumeier C, Saussenthaler S, Kammel A, Jhnert M, Schlter L, Hesse D, et al

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