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Fat loss depends on energy deficit only, independently of the method for weight loss

Closing: The Clinical Bottom Line on Tesamorelin Tesamorelin stands apart from most peptides because it has a documented clinical evidence base, an FDA-approved indication, and a mechanism that is well understood at the molecular level

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We furthermore thank Luise Krauth-Siegel for helpful discussions and Tobias Dick and Bruce Morgan for reading an initial version of the manuscript and suggestions

Clinical trial data from the STEP program showed that semaglutide 2.4mg weekly produced average weight loss of 14.9% of body weight over 68 weeks, compared to tirzepatide at 15mg which achieved approximately 22.5% in the SURMOUNT trials