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Semaglutide interacted with circumventricular organs, where GLP-1R expression is abundant, and with regions protected by the BBB (lateral septal nucleus, nucleus tractus solitarius, hypothalamic arcuate nucleus) (102)
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Furthermore, the well documented efficacy of combined folic acid, B6, and B12-vitamin supplementation to reduce hyperhomocysteinemia could enhance GSH activity and reduce oxidative stress (161)
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