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How GLP-1s work GLP-1 is short for glucagon-like peptide-1, a hormone in your digestive tract that your body releases when you eat

Tereak P, Lapao A, Subic N, Boya P, Elazar Z, Simonsen A

Research suggests GIP activation improves insulin sensitivity in adipose tissue, may contribute to central nervous system appetite regulation beyond what GLP-1 provides, and appears to reduce some of the gastrointestinal side effects associated with GLP-1 agonism alone

Likewise, sometimes you'll need to give your body more time to adjust when you shift between dosages or start the medication for the first time