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In a comprehensive 2015 review published in BioMed Research International , Pickart and colleagues integrated three decades of preclinical and clinical research on GHK-Cu, reporting that the molecule stimulates collagen, elastin, glycosaminoglycan, and decorin synthesis in human dermal fibroblasts

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This is a concise, yet comprehensive summary of the understanding of psoriasis pathophysiology and of the topical, light-based and biologic therapies that are used to treat the disease

Pre-clinical data points to upregulation of nerve growth factor and vascular endothelial growth factor in injury models, supporting interest in nerve regeneration and angiogenesis applications