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This is why Fishman says those with a history of anxiety and insomnia arent great candidates for a bupropion-naltrexone prescription, and thats also why it carries a warning from the FDA that it may lead to suicidal thoughts and behaviors (though the risk is very small)

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While its usually not a cause for serious concern, a reaction on your face could indicate that your body is reacting to the medication in an unexpected or undesirable way