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Robert Recker, a bone metabolism researcher at Creighton University whose work on bisphosphonate adherence has been cited in over 200 publications, has noted that "the single most modifiable predictor of bisphosphonate treatment failure is incorrect administration timing," a finding consistent with the adherence data in the POSSIBLE US observational study (N=over 15,000 osteoporosis patients)

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Seizures have been associated with L-carnitine use in those with and without seizure disorders

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The slow start is likely to frustrate patients who cannot afford to buy the drugs and comes after an extremely slow rollout of weight-loss injections on the health service