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Per the American Diabetes Association (ADA) Standards of Care in Diabetes2026, diagnosis is confirmed by one of four criteria: fasting plasma glucose 126 mg/dL, 2-hour plasma glucose 200 mg/dL during a 75-g OGTT, A1C 6.5% (using an FDA-approved CLIA-certified method), or a random plasma glucose 200 mg/dL in a patient with classic hyperglycemia symptoms

See the Tirzepatide protocol page for the standalone reference

These changes are gradual

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Oral forms must pass through the digestive system, which can lead to variability in absorption, while injectable or IV forms enter the bloodstream directly under medical supervision