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We therefore developed dual-GLP-1/GIP receptor agonists that can cross the BBB at an enhanced rate and showed superior protective properties on synapses in animal models of AD and PD

pSMAD2 is correspondingly reduced by follistatin-344 (5262% versus vehicle)

Rojas-Ramos et al., 2003) coupled to the CCR3 receptor, while IL-4 and IL-3 favor the change of immunoglobulin (Ig) isotype in B cells, with the subsequent production of IgE (Figure 1)

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In this review we will discuss the evidence which suggests renoprotection induced by GLP-1 receptor agonists and the potential mechanisms that may be involved