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Defectos del tubo neural Se sabe que el folato es crtico para el desarrollo embrionario normal, y la suplementacin materna con cido flico disminuye la incidencia de defectos del tubo neural (DTNs) (56)

H.YildirimZ.et al (2019)

An apparent paradox is that whereas GLP-1 increases glucose-stimulated insulin secretion in the isolated pancreas fulfilling the definition of an incretin but it lowers insulin secretion in physiologically relevant conditions [6, 10, 18]

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Because of their peptide structure, GLP-1 receptor agonists are susceptible to poor gastrointestinal permeability, cytosolic metabolism, and hepatic clearance mechanisms that result in poor oral bioavailability