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Also, P rats have been shown to exhibit an anxiety-like phenotype and may be more sensitive to the effect of NK1R antagonists on reducing negative reinforcement for alcohol (Stewart et al., 1993)
When changing any transdermal patch, patients should remove the old patch carefully, fold it in half with the adhesive sides together, and dispose of it safely according to the medication guidetypically in a sealed container out of reach of children and pets
However, safety and efficacy of metformin extended-release tablets in the pediatric population have not been established
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