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Parkinsons disease PD is a progressive neurodegenerative disorder caused by the neuronal death in the substantia nigra (SN), degeneration of dopaminergic neurotransmission, and the presence of -synuclein and protein inclusions in neuronal cell bodies (Lewy bodies) [4-5,7]
for these reasons, mPTP is widely considered as the final step of cell demise 44
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The vitamin supplements, but not the placebo significantly reduced all 4 metabolite concentrations (methylmalonic acid, homocysteine, 2-methylcitric acid and cystathionine)
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