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Glucagon receptor agonism in metabolic disease: revisiting an old target
The absence of regulatory guidelines around dosage, frequency, and duration further complicates safety evaluations
SGLT2 inhibitors fix this problem by activating the peroxisome proliferator-activated receptor gamma coactivator 1 ( PGC-1 ) pathway to make new and healthy mitochondria (Afsar et al., 2021)
One mouse study found no increase in mean lifespan, although maximum-lifespan measurements among the longest-surviving animals changed
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