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386,387 Autophagy-inducing small molecules and natural compounds Additional autophagy-inducing agents include lithium, which induces autophagy via inhibition of inositol monophosphatase and reduces tau and amyloid- aggregation in AD models, 388 and SMER28, a small-molecule enhancer of rapamycin that promotes autophagy and reduces tau and -synuclein aggregation in AD and PD models
Expression levels of the BDNF gene and histone modifications around its promoters in the ventral tegmental area and locus ceruleus of rats during forced abstinence from morphine
The peptide decreased the fluorescence intensity of H2AX signals, a marker of DNA damage, and appeared to have lowered apoptosis rates as indicated by Annexin-V staining
To do so, more functional studies that involve specific molecular markers and targeted inhibitors are necessary
Toxics 10 (1), 11
