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When brain glutathione is depleted, the delicate neuronal lipid membranes undergo lipid peroxidation, and the protective blood-brain barrier becomes compromised

Researchers often examine it in models involving neuronal signaling, synapse formation, and learning-related pathway behavior

Abbreviations BLAST: Basic Local Alignment Search Tool CAI: Codon adaptation index CASP: Critical Assessment of protein Structure Prediction DNA: Deoxyribonucleic acid GDT-HA: Global distance test high accuracy GRAVY: Grand Average of Hydropathy HMM: Hidden Markov Models IDRs: Intrinsically disordered regions II: Instability index Ig: Immunoglobulin JCat: Java Codon Adaptation Tool Kd: Dissociation constant MEV: Multi epitope vaccine SS-MEV-1: Strongyloides stercoralis multi epitope vaccine MW: Molecular weight NMA: Normal-mode analysis PDB: Protein Data Bank pI: Isoelectric pH pLDDT: predicted Local Distance Difference Test PRODIGY: PROtein binDIng enerGY RMSD: Root Mean Square Deviation SP: Signal peptide SS: Strongyloides stercoralis TM: Transmembrane WHO: World Health Organization References Schar F, et al

Evolving basic, pathological and clinical concepts in PD