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Tissue samples were examined for macroscopic damage assessed by a single observer (M.S.) blinded to characteristics or treatment of the animal being studied, according to previously described criteria (Mourelle et al, 1996) that takes into account (1) presence of adhesions (score 02), (2) strictures (score 03), (3) ulcers (score 03), and (4) wall thickness (score 02)

However, results are limited by the small size, short duration, and lack of long-term follow-up [1][60]

Additionally, glutathione supports overall skin health by detoxifying the body, repairing cells, and stimulating collagen synthesis

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Beyond hyperglycemia, dysregulated lipid metabolism, oxidative stress, and inflammation drive early disease ( This review focuses on PUFA metabolism and eicosanoid signaling as upstream drivers of early DR, and highlights selected modifiable metabolic factors, including Hcy, that may enhance lipid-mediated oxidative and inflammatory signaling within the retinal neurovascular unit