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When it senses threats like UV rays or inflammation, it cranks up production to protect you
Over time, oxidative stress can lead to cellular damage, which is strongly linked to cognitive decline, mild cognitive impairment, Alzheimers disease, and other neurological disorders
However, when excessive amounts of acetaminophen are ingested, the livers supply of glutathione can be depleted rapidly, leaving NAPQI unneutralized.[ref] Glutathione is the master antioxidant, but there are several situations in which glutathione levels may already be low and thus unable to rise to the occasion for high doses of acetaminophen
Change history 01 July 2026 In the version of this article initially published, in the Source Data for Fig
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