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However, CJC-1295 (especially the DAC version) can cause sustained elevation in IGF-1, whichif mismanagedmay increase the risk of: Insulin resistance Carpal tunnel syndrome Soft tissue growth (in rare, prolonged cases) Pituitary overstimulation That said, these issues are more often associated with excessive dosing or continuous high-frequency use

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Human studies remain diverse yet increasingly instructive

The curve follows a characteristic pattern that researchers should anticipate

Continuing at a stable, lower dose is often superior to pushing toward maximum dose and risking side effects that compromise adherence