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Here, we review the physiology and pharmacology of GLP-1 agonists, their current clinical indications, nuanced perioperative considerations, and areas of research needed to establish the safest use of these agents for our patients

Moreover, prior trials have suggested potential safety concerns with GLP-1 receptor agonists in patients with heart failure with reduced ejection fraction (HFrEF), so the lack of any safety issues among patients with the lowest EFs in STEP-HFpEF also is certainly reassuring, Vaduganathan said

Simran Malhotra, M.D., is a board-certified lifestyle medicine physician and wellness coach

Prescribing an unapproved new drug outside a trial is technically illegal under the FDCA (aside from narrow compassionate-use exceptions)

For autoimmune patients who also have metabolic syndrome, these changes address a significant contributor to their overall inflammatory burden