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Regulatory Status Summary (as of July 29, 2026) Category 2 restricted status: Removed (April 2026) FDA approval: None USP/NF monograph: None 503A Bulks List: PCAC recommended inclusion (July 2324, 2026, nonbinding)
Canagliflozin reduced the risk of the primary composite outcome (ESKD, doubling of serum creatinine, or renal or cardiovascular death) by 30% compared to placebo, with consistent effects across all prespecified subgroups [46]
Other CICA derivatives (Asiatic Acid and Madecassic Acid) helps calm the skin, reduce irritation, and strengthen the skin barrier
Inflamm Bowel Dis (2010) 16:7686
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