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GLP-1 RA Use Improves Disease Activity, Cardiovascular Risk in Rheumatoid Arthritis Abigail Brooks, MA Ryan Livingston Key Takeaways GLP-1 RAs may reduce RA disease activity, pain, and cardiovascular risk factors in patients with RA and obesity

However, she cautioned that "theyre not technically allowed to, but its also unclear how much the FDA will enforce this new regulation." Impact on Weight-Loss Efforts For those who discontinue GLP-1 medications like Ozempic and Wegovy, studies indicate that most will regain up to two-thirds of the weight they lost within a year

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Safety data is similarly limited, with the tolerability of creams and long-term effects sparsely analyzed in the literature

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