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Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor
For drug development, the GLP-1 receptor agonist structure should also be considered, since ligand orientation, peptide modifications, and half-life-extending features directly influence pharmacokinetics and receptor interactions
But walking alone wont preserve muscle
At the central level, GLP-1 receptors are expressed in regions of the hypothalamus and brainstem that govern appetite and food-seeking behavior
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