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Although CPT1A and CPT1B exhibit considerable sequence similarity, the sensitivity of these two enzymes to their physiological inhibitor, malonyl-CoA, differs greatly (CPT1A has a ten-fold higher Ki for malonyl-CoA) 39,40
Importantly, controlled clinical trials directly measuring tendon/ligament healing, muscle repair and objective inflammatory biomarkers in humans are lacking, and most mechanistic insights still come from animal models
study on epithalon's effects in test animals also included a clinical component that involved 12 volunteers taking the peptide and 8 volunteers given placebo
doi:10.3390/molecules26092675 Matsuzaki S, Darcha C
