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The main effect of endogenous GIP regarding weight is primarily on adipose tissue, where it promotes positive energy balance
On glycemic control, it selectively boosts insulin synthesis and secretion from pancreatic -cells when blood glucose rises, meanwhile restraining excessive glucagon release from -cells to cut hepatic glucose overproduction, and protects islet cells against inflammatory apoptosis to preserve long-term pancreatic function
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Next, we analyzed the effect of Hex treatment on the ionotropic calcium influx through NMDA and AMPA receptors in the hippocampal slices of 5XFAD mice with functional PPAR, 5XFAD Ppar-null mice with global knockdown of PPAR, and 5XFAD Ppar-Hippo mice with hippocampus-specific deletion of PPAR
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