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The SELECT trial's cardiovascular benefit data (20% MACE reduction) has been particularly influential in changing payer attitudes, because preventing heart attacks and strokes saves money long-term

Akkermansia muciniphila gen

But the level of obesity in the US is absolutely a public health crisis, presents massive costs on both a personal and societal level and in large part seems to perpetuate as a disease state (Metabolic Syndrome etc) - its completely reasonable to think that modern science can cure this condition which is largely a symptom of modern lifestyles anyway

Endocrinology (2021) 162(8):bqab079

This molecule bore a striking resemblance to human glucagon-like peptide-1 (GLP-1), a hormone naturally produced in the gut that plays a crucial role in regulating blood sugar and appetite