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Avoid any other sources of stimulants while using

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Diverticular disease has been noted in patients with clEDS (6/31 patients in the literature) and in our cohort two patients (P6, P17 [terminal ileum, colon]) had proven and one suspected colonic diverticulosis

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In particular, the positive impact on maximal effect (E max ) in this assay format significantly improves the chances of identifying weak agonists during high-throughput screening (HTS)