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They can improve blood pressure, lipid profiles, and endothelial function, which are crucial for a healthy cardiovascular system and reducing cardiovascular risk factors
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Sitagliptin improves vascular endothelial function in Japanese type 2 diabetes patients without cardiovascular disease
Consistent with the observations in human elderly Leydig cells, H2O2-induced senescent TM3 Leydig cells exhibited a predominant nuclear localization of FOXO4, in contrast to untreated controls where it remained mostly cytoplasmic
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