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It circulates endogenously in plasma, saliva, and urine, where it works as a signalling molecule rather than a structural protein fragment

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Gastrointestinal AE with cagrisema were more than with semagutide or cagrilintide monotherapy, however the SAE and AE leading to medication discontinuation were minimal and similar between the groups [87, 90] A programme of phase 3 clinical trials (REDEFINE) assessing the safety and efficacy of cagrisema in people with obesity (NCT05567796, NCT05394519, NCT05813925) is currently ongoing

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Pushing a single peptide to its ceiling is where the harshest side effects tend to live, because you are forcing one receptor system to do everything