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Tell your healthcare provider if you have any of the following symptoms, which could indicate a problem with your thyroid (Novo Nordisk, 2021): A lump or swelling in your neck Hoarseness Trouble swallowing Shortness of breath It isnt common, but Rybelsus can cause complications for people with certain health conditions including (Novo Nordisk, 2021): Pancreatitis Diabetic retinopathy (damage to the eye from diabetes) Renal (kidney) problems Its not recommended to take this medication while youre pregnant or breastfeeding