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The study did not show a clinically meaningful change in either hormones exposure: ethinyl estradiol exposure (level) was essentially unchanged, and levonorgestrel exposure (level) increased modestly (by less than 20%), in a way that, if anything, would maintain or improve contraceptive effectiveness
In total, more than 500 muscle fibers were evaluated per sample using ImageJ software to ensure sufficient statistical assessment [2]
Further study is still needed to understand any potential long term risks associated with this medicine use
Subsequently, cells were blocked in 2% BSA (Euromedex, 04-100-812-E), 0.2% Tween-20 and 1 PBS (blocking buffer) for 20 min at room temperature
( A ) Representative images of pancreas sections immunostained for insulin (red), glucagon (green), and DAPI in cell GLP-1R WT and KO mice treated with saline (CTRL) or liraglutide (LIRA)
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