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Certain MC1R variants reduce the capacity for repair to damaged DNA [5], while the process of melanin biosynthesis, particularly of pheomelanin, may itself generate reactive oxygen species and other by-products that may be cytotoxic, genotoxic, or mutagenic causing DNA damage [4, 6]
This information guides not only semaglutide dosing but also the choice between semaglutide and tirzepatide, or dual-compound formulas like GLP-Squared
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