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Because energy and metabolism are closely tied to B12, many people began linking it with weight loss, and thats how Vitamin B12 shots for weight loss became popular

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A deficiency can creep up gradually, making it easy to dismiss symptoms as stress or simply getting older. However, if left untreated, low B12 levels can lead to serious health issues

doi:10.1017/S1461145711000617, PMID: 21733244 Gawryluk JW, Wang JF, Andreazza AC, Shao L, Young LT (2011) Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders

The physiological relevance of an electrochemical parameter measured under such artificial conditions may be questioned