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Vairetti M, et al

Benefit from the biotin boost

After starting and after each dose increase, tirzepatide can cut the peak absorption of an oral contraceptive by more than half, so the label guidance is a non-oral method or added barrier protection for four weeks after starting and four weeks after each increase. It is a first-dose-and-escalation effect, not a permanent block on all oral drugs

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However, PPP inhibition has minimal impact on trained immunity, suggesting a limited role in this process (50)