ALS usually occurs in the middle-aged and elderly population, with a prevalence of 4.18.4 per 100,000 people, and is characterized by progressive loss of upper and lower motor neurons at the spinal cord or medullary level (259, 260)
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Omega-3 PUFAs, particularly EPA, are potential remedials to reduce pro-inflammatory cytokines, alter the HPA axis, modulate neurotransmission via lipid rafts, and alleviate neuro-cognitive complications in PASC patients 714
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