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ABSTRACT KEY FIGURE Highlights INTRODUCTION DISCOVERY OF GLP-1 AND DEVELOPMENT OF INCRETIN-BASED DRUGS GLP-1 AND IMPLICATIONS IN COGNITIVE SATIATION: HUMAN STUDIES HYPOTHALAMIC FUNCTIONS IN COGNITIVE FEED-FORWARD REGULATION HYPOTHALAMIC CONTROL OF GLP-1 ACTIONS ON SATIATION AND SATIETY: ANIMAL STUDIES ONGOING FUTURE STUDIES OF GLP-1R AGONISTS NOTES REFERENCES About this article ABSTRACT Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as blockbuster drugs for treating metabolic diseases
GLP-1 Injections: Wegovy (semaglutide) and Zepbound (tirzepatide)
The FDA's prescribing information for Wegovy lists the option to delay dose escalation by 4 additional weeks at any tier if GI tolerability is a concern [15]
The same signal has been observed at high rates with Wegovy 7.2 mg, suggesting its an effect in the higher doses of GLP-1 medications rather than something specific to retatrutide
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