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Reflux is causing documented esophagitis on endoscopy that is not improving

Outside of GLP-1s, medications such as metformin, SGLT-2 inhibitors (such as Jardiance), or even certain off-label medications such as low-dose naltrexone may also support weight management or blood sugar control when used as part of a comprehensive approach, Abeyta says

Its triple receptor agonism targeting GLP-1R, GIPR, and GcgR simultaneously produces a metabolic profile that surpasses earlier GLP-class compounds in published clinical research across Phase 2 and Phase 3 trials

This results in improved insulin sensitivity and a significant reduction in blood glucose levels

But for selected men especially those with low motility, oxidative-stress concerns, or male fertility optimisation goals it may be considered as part of a broader support plan under professional guidance