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Semaglutide is a GLP-1-only agonist, while tirzepatide activates both GLP-1 and GIP receptors simultaneously, producing stronger appetite suppression and metabolic effects in many patients

They typically describe one patient, and therefore do not demonstrate comprehensive proof of a drug effect for all users, only a one-off situation where this has occurred

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For a GLP-1 program to succeed in the long term, we include simple nutritional coaching