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Tirzepatide: Dual GLP-1/GIP Agonist Tirzepatide activates two receptor types simultaneously: GLP-1 (Glucagon-like peptide-1): Slows gastric emptying, reduces appetite, and enhances insulin secretion GIP (Glucose-dependent insulinotropic polypeptide): Improves insulin sensitivity and may have direct effects on fat tissue Retatrutide: Triple GLP-1/GIP/Glucagon Agonist Retatrutide includes everything tirzepatide does, plus a third target: GLP-1: Same appetite suppression and insulin benefits GIP: Same metabolic and insulin sensitizing effects Glucagon receptor: Increases energy expenditure, promotes fat oxidation, and may help preserve lean muscle mass Why Glucagon Matters Glucagon shifts the body toward burning stored fat for energy and increases metabolic rate

Tirzepatide has the ability to cause stomach upset, loss of appetite, tiredness, and constipation

Rather than focusing solely on calorie counting, aim for a diet rich in: Lean proteins (chicken, fish, legumes, eggs) which support satiety and help preserve muscle mass during weight loss, which is particularly important given that GLP-1-based therapies may reduce lean mass alongside fat if protein intake is insufficient Fibre-rich vegetables and wholegrains which slow gastric emptying and complement the drug's appetite-suppressing effects Healthy fats (olive oil, avocado, nuts) in moderate quantities to support hormonal health Minimally processed foods reducing reliance on ultra-processed products that are engineered to override satiety signals If you have chronic kidney disease or other conditions affecting protein metabolism, speak to your clinical team before significantly increasing protein intake

9 The types of activities you may find more helpful are both physiological and psychological relaxation exercises before retiring

Fertility, PCOS, and IVF on Wegovy The Wegovy SmPC states that the effect of semaglutide on human fertility is unknown