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Winneke et al., 1996)

Reasonable expectations (what success typically looks like clinically) Success is: Better appetite control without daily misery Steady fat loss while maintaining strength and function Improved lab and metabolic trends when relevant A plan you can live with after the active loss phase ends If the only metric is rapid scale loss, patients often pay for it laterwith regain, fatigue, hair shedding, constipation, or loss of lean mass

The Glutamate/(serine + glycine) Index (you can calculate in practice this with a plasma amino acid panel) Another key study by Gaggini, M

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While adequately powered for the primary outcome, 1415 patients per group is relatively small