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Choose tirzepatide when Tirzepatide makes more sense for users who have plateaued on semaglutide, need greater weight loss (beyond 15% body weight), prefer more dosing flexibility with optional intermediate tiers, or are particularly sensitive to nausea and want lower rates of this side effect

Standalone or combinatorial regimens designed around potent bio-absorptive reductants, elevating the efficiency of palliative treatment by decreasing or delaying disease progression, will be a welcome step for further trials and those affected by the disease

Mater Adv 6(3):10511066 Funding The authors declare that no funds, grants, or other support were received during the preparation of this manuscript

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