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As you age, GHRH pulse amplitude decreases, your pituitary gets less stimulation, and your growth hormone output drops
It acts as a cofactor along with SHMT for the formation of methylfolate
Taken together, the figure highlights a key mechanistic principle underlying the therapeutic rationale for multi-agonist strategies: while GLP-1R monotherapy achieves meaningful metabolic and hepatic benefits exclusively through indirect, systemic pathways, the addition of GIPR and - most importantly - GCGR co-agonism introduces complementary and increasingly direct hepatic mechanisms, providing the pharmacological basis for the superior efficacy observed with dual and triple agonists in MASLD/MASH
9 GLP-1RAs should not be prescribed in patients with a history of pancreatitis, a personal or family history of medullary thyroid cancer, or multiple endocrine neoplasia due to the observed development of thyroid tumors in animal studies
Together these three treatments target dull, tanned, and uneven summer skin from both the inside and the outside, delivering visible brightening and smoother texture in fewer sessions than doing each treatment separately
