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Once-weekly injection : It only requires once-a-week injections, making it convenient compared to daily treatments
Determination of intrahepatic triglyceride content Mouse livers were collected and immediately frozen and stored at 80 C
A.W.P.), the Leverhulme Trust (F/00 182/CN
[11] The hypothesis underlying microdosing is that lower doses might provide some metabolic benefit whilst minimising these troublesome symptoms, potentially improving treatment adherence
There were also some improvements in surrogate markers of fibrosis measured by MRE (36% and 33% of patients in the 10 mg daily and 20 mg weekly arms, respectively, had 15% reduction in liver stiffness compared to 7% in the control arm) and pro-C3, as measured by adjusted percent improvement from baseline (30%, 21% and 1.9% in the 10 mg daily, 20 mg weekly, and placebo arm, respectively)
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