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Glutathione deficiency leads to: Increased oxidative stress Accumulation of toxins and heavy metals Inability to repair DNA Cell mutation Reduced supply of oxygen and nutrients to the cells Eventual cell death People who consider themselves to be in good health may not necessarily be glutathione deficient but may still have declining glutathione levels

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They are expressed throughout the central nervous system, including in brain regions that regulate reward, motivation, and pleasure

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1